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白血病是儿童最常见的肿瘤,了解白血病的起源对白血病的预防有重要的指导意义。洪登礼实验室的系列研究证实儿童白血病多起源于胚胎造血,这为进一步研究白血病起源机制,寻找预防措施打下重要基础。白血病治疗失败的主要原因是不能有效清除白血病干细胞(leukemia-propagating cells,LPCs),导致复发。最近,洪登礼研究室发现并报道,急性淋巴细胞白血病化疗在骨髓中诱导形成一个新的微环境(niche),保护LPCs免受化疗杀伤,导致治疗失败。该微环境被命名为治疗诱导微环境(therapy-induced niche,TI-niche)。系统靶向TI-niche有望彻底清除体内残留的LPCs,提出白血病的靶向治疗新策略。
Leukemia is the most common tumor in children. Understanding the origin of leukemia has an important guiding significance for the prevention of leukemia. A series of studies by Hong Dengli laboratory confirmed that most childhood leukemia originated from embryonic hematopoiesis, which lays an important foundation for further research on the mechanism of the origin of leukemia and the search for preventive measures. The main reason for the failure of leukemia treatment is that it can not effectively remove leukemia-propagating cells (LPCs), leading to recurrence. Recently, the Hongde Li laboratory found and reported that chemotherapy with acute lymphoblastic leukemia induced a new niche in the bone marrow that protected LPCs from chemotherapy killing, leading to failure of treatment. This microenvironment is named therapy-induced niche (TI-niche). The systematic targeting of TI-niche is expected to completely eliminate residual LPCs in vivo and propose a new strategy of targeted therapy of leukemia.