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维甲酸（ＨＲＡ）是近年来被国内外学者广泛研究、效果显著的一类抗肿瘤新药．它不仅对骨的生成，上皮细胞的生长有调控作用；对化学致癌物诱发的皮肤、乳腺、胃、头颈癌等也有一定的预防及抗瘤作用［１，２］．但因毒副作用较大影响了临床上的广泛应用．Ｎｉ（ＲＡ）２·３Ｈ
Retinoic acid (HRA) is a kind of antitumor new drug widely researched by domestic and foreign scholars in recent years. It not only has a regulation on the formation of bone and the growth of epithelial cells, but also has certain preventive and anti-tumor effects on the skin, breast, stomach, head and neck cancer induced by chemical carcinogens. However, a greater impact on the clinical application of a wide range of side effects. Ni (RA) 2 · 3H