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目的:研究大黄配伍药后对其泻下作用的变化及其共性关系。方法:将140只实验动物随机分为生理盐水组、果导组及大黄药对组(15 g·kg~(-1)、7.5 g·kg~(-1),以大黄生药计),按10 mL·kg~(-1)的剂量给药后,分别用代谢笼积分法、酚红糊排空法、炭末推进作用及Na~+-K~+-ATPase活性实验,比较大黄配伍药对对大鼠的正常泻下作用、酚红糊肠推进功能、炭末推进率及Na~+-K~+-ATPase活性。结果 :大黄与药对配伍后泻下作用均有不同程度的改变,与生理盐水组比较,大黄、大黄牡丹及大黄桃仁15 g·kg~(-1)剂量组显著增加正常小鼠泻下作用、促进肠推进功能、提高炭末推进率及抑制Na~+-K~+-ATPase活性,表明其泻下作用有显著差异;且与大黄组比较,大黄桃仁及大黄牡丹配伍后的泻下作用有差异,其中泻下作用最显著的是大黄牡丹组。结论:大黄与牡丹、桃仁、甘遂配伍可促进其泻下作用,与枳实、黄连配伍则可抑制其泻下作用,这可能与配伍中药的主要化学成分引起大黄中蒽醌类化合物的溶出量变化及药对间的相使相须作用有关。
Objective: To study the changes of rhubarb after its compatibility with drugs and its common relationship. Methods: 140 experimental animals were randomly divided into normal saline group, lead group and rhubarb group (15 g · kg -1, 7.5 g · kg -1) After the dose of 10 mL · kg ~ (-1) was administered, metabolic cage integral method, phenol red paste emptying method, charcoal propulsion and Na ~ + -K ~ + -ATPase activity were compared respectively. Right normal diarrhea in rats, phenol red paste intestinal propulsion function, carbon propulsion rate and Na ~ + -K ~ + -ATPase activity. Results: Compared with saline group, Rhubarb, Rhubarb peony and rhubarb peach kernel 15 g · kg -1 significantly increased the diarrhea effect of normal mice , Promote the function of intestinal propulsion, increase the rate of charcoal propulsion and inhibit the activity of Na ~ + -K ~ + -ATPase, indicating that there is a significant difference in its diarrhea effect. Compared with the rhubarb group, the diarrhea effect of rhubarb peach and rhubarb peony There are differences, of which the role of diarrhea is the most significant rhubarb peony group. Conclusions: Rhubarb and peony, peach kernel and kansui root can promote its diarrhea, and its combination with citrus aurantium and berberine can inhibit the diarrhea effect, which may be related to the main chemical components of traditional Chinese medicine cause the dissolution of anthraquinones in rhubarb Volume changes and the phase of the drug between the phase effect to be related.