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目的 对鼻咽癌 (NPC)进行临床与病理观察 ,进一步认识其临床病理特性。方法 分析 2 6 7例鼻咽癌的临床病理资料。结果 本组鼻咽癌 30～ 5 9岁者 2 19例 (82 .0 % ) ;男性 181例 (6 7.8% ) ;农民 2 5 1例 (94 .0 % ) ;临床首发症状表现为颈部淋巴结肿大者 2 0 1例 (75 .3% ,P <0 .0 1) ;病变累及鼻咽顶部者 16 1例 (6 0 .3% ) ;粘膜下浸润型 117例(43.8% ) ;分化差者包括低分化鳞癌和未分化癌 2 2 1例 (82 .8% ,P<0 .0 1)。结论 本组病例以 30～ 5 9岁、男性、农民多见 ;病变常累及鼻咽癌顶部 ,临床首发症状多表现为颈部淋巴结肿大 ;分化差的癌多 ,恶性程度高 ,揭示预后不良 ;粘膜下浸润型明显偏多 ,对可疑病例均应进行鼻咽粘膜盲目活检 ,以便早期诊断 ,早期治疗。
Objective To observe the clinical and pathological features of nasopharyngeal carcinoma (NPC) and to further understand its clinicopathological features. Methods Clinical data of 267 cases of nasopharyngeal carcinoma were analyzed. Results 19 cases of nasopharyngeal carcinoma (82.0%) were aged 30-59 years; 181 (6 7.8%) were male; 25 cases (94.0%) were farmers; the first symptom of clinical manifestation was neck There were 201 cases (75.3%, P <0.01) of lymphadenopathy; 16 cases (60.3%) had lesions involving the top of nasopharynx; 117 cases (43.8%) of submucosal infiltration; Poorly differentiated patients included poorly differentiated squamous cell carcinoma and undifferentiated carcinoma (21 cases, 82.8%, P <0.01). Conclusion This group of patients 30 to 59 years old, more common in men and peasants; lesions often involve the top of nasopharyngeal carcinoma, the clinical manifestations of the first symptoms of cervical lymph node enlargement; poorly differentiated cancer and more malignant, revealing a poor prognosis ; Submucosal infiltration was significantly more, suspected cases of nasopharyngeal mucosa should be blind biopsy for early diagnosis and early treatment.