(一)概述碳青霉烯类抗生素属于非典型的β-内酰胺类抗生素,其母核的特征是将青霉素的1位硫原子被碳原子所取代,且噻唑环中2位和3位具有不饱和双键,从而组成碳青霉烯类(Carbapenems)。和典型β-内酰胺不同,其6位具有α位羟乙基侧链,典型β-内酰胺都具有β位胺基侧链,同时碳青霉 (A) Overview Carbapenem antibiotics belong to the atypical β-lactam antibiotics, the characteristics of its mother nucleus is penicillin sulfur atom is replaced by a carbon atom, and thiazole ring 2 and 3 have Unsaturated double bond to form carbapenems (Carbapenems). Unlike the typical β-lactam, which has the α-hydroxyethyl side chain at position 6 and the typical β-lactam has the β-amino group side chain,