大量实验证实,吸烟者肺气肿是由于中性白细胞弹性蛋白酶作用于肺内弹性蛋白所致。已证明秋水仙素能减少中性白细胞弹性蛋白酶的分泌,为此进一步观察秋水仙素对吸烟的肺气肿患者的临床疗效.实验为前瞻性、双盲、随机且有安慰剂对照。16例患者年龄45～75岁,皆为过度吸烟者,有肺部病史,1秒钟用力呼气容积(FEV 1)小于预计值的75%,但多于1.2L。应用支气管扩张剂后,其气流 A large number of experiments confirmed that smokers emphysema is due to the role of neutrophil elastase in the lung caused by elastin. Colchicine has been shown to reduce neutrophil elastase secretion in order to further investigate the clinical efficacy of colchicine on smokers with emphysema. The trial was a prospective, double-blind, randomized placebo-controlled trial. Sixteen patients aged 45-75 years, all of whom were over smokers, had a history of lung disease and had a forced expiratory volume per second (FEV 1) of less than 75% of their predicted value, but more than 1.2L. After the application of bronchodilators, the airflow