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目的 探讨环磷酸鸟苷 (c GMP)在妊高征发病中的作用。 方法 采用放射免疫法测定 12 4例正常妊娠各期、32例妊高征患者及 30例健康对照者血浆 c GMP浓度。其中 32例正常足月孕妇和 32例妊高征患者于剖宫产时取胎盘组织测其匀浆 c GMP浓度。 结果 (1)正常妊娠各期血浆 c GMP(2 6 .2 5± 4.30 )、(2 3.40± 4.5 4)、(2 6 .2 0± 6 .6 0 )、(34 .14± 8.41)、(32 .32± 8.11) nm ol/ L 显著高于健康对照者 (2 0 .2 2± 3.44 ) nm ol/ L (P均 <0 .0 5 )。 (2 )妊高征血浆及胎盘 c GMP(2 8.49± 8.98) ) nmol/ L与 (2 .76± 0 .49) nmol/ g均显著低于正常足月孕妇 (34 .14± 8.41) nmol/ L与(3.78± 0 .81) nmol/ g(P<0 .0 5 ,P<0 .0 0 1)。轻度妊高征患者血浆及胎盘 c GMP显著高于中度及重度患者 (P<0 .0 0 5 ,P<0 .0 5及 P<0 .0 5 ,P<0 .0 0 1)。妊高征患者血浆及胎盘 c GMP与舒张压均呈负相关 (P<0 .0 5 ,P<0 .0 5 )。 (3)妊高征患者胎盘 c GMP显著低于其血浆 c GMP(P<0 .0 0 1)。 结论 妊娠期间胎盘产生的 c GMP可能在妊高征的发病中起重要作用
Objective To investigate the role of cGMP in the pathogenesis of PIH. Methods Radioimmunoassay was used to determine plasma c GMP concentrations in 124 normal pregnant women, 32 PIH patients and 30 healthy controls. 32 cases of normal term pregnant women and 32 cases of pregnancy induced hypertension in cesarean section were taken from the placenta tissue to measure the concentration of c GMP. Results (1) The levels of plasma c GMP (2 6 .25 ± 4.30), (2.40 ± 4.5 4), (2.60 ± 6.60), (34.14 ± 8.41) (32.32 ± 8.11) nm ol / L was significantly higher than that of healthy controls (20.22 ± 3.44) nm ol / L (P <0.05). (2) Plasma and placental cGMP (2 8.49 ± 8.98) nmol / L and (2.76 ± 0.49) nmol / g of PIH were significantly lower than those of normal full-term pregnant women (34.14 ± 8.41) nmol / L and (3.78 ± 0.81) nmol / g (P <0.05, P <0.001). The plasma and placental c GMP levels in patients with mild PIH were significantly higher than those in moderate and severe patients (P <0.05, P <0.05, P <0.05, P <0.01) . Plasma and placental c-GMP in patients with PIH were negatively correlated with diastolic pressure (P <0.05, P <0.05). (3) The placental c GMP in patients with PIH was significantly lower than that of plasma c GMP (P <0.01). Conclusion The placental c GMP during pregnancy may play an important role in the pathogenesis of PIH