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目的 探讨高原低氧对大鼠学习记忆脑高级功能的影响及其神经机制。方法 两组大鼠分别在模拟海拔 5 5 0 0 ,6 0 0 0米高度的低压舱内每天生活 2小时 ,连续一周 ,然后观察其爬杆反应行为学指标以及海马神经元突触结构参数变化。结果 与对照组相比 ,海拔 6 0 0 0米低压低氧组大鼠出现爬杆条件回避反应的习得和保持率下降 ,突触后致密物质 (PSD)厚度下降 ,长度缩短 ,突触间隙相应增宽 ,突触穿孔现象减少。 5 5 0 0米组无上述作用。结论 海马神经元突触结构异常是低压低氧条件下大鼠学习记忆脑高级功能障碍的形态学基础。
Objective To investigate the effect and mechanism of plateau hypoxia on learning and memory function of high brain in rats. Methods Rats in the two groups were allowed to live 2 hours a day in the low-pressure cabin at a height of 550,000 and 60,000 meters respectively for 1 week. The changes of behavioral parameters and the synaptic structure of hippocampal neurons were observed . Results Compared with the control group, the acquisition and retention rate of climbing pole avoidance in the hypoxic hypoxia group at 6 000 m altitude decreased, the thickness of the postsynaptic density (PSD) decreased, the length shortened, and the synaptic cleft The corresponding broadening, reducing the phenomenon of synaptic perforation. The 5 0 0 meter group did not have the above mentioned effect. Conclusions Synaptic structural abnormalities in hippocampal neurons are the morphological basis of learning and memory impairment in rats under hypobaric hypoxia.