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目的探讨复发妇科恶性肿瘤患者HIF-1α、EGFR的表达及其与放射敏感性的关系。方法采用免疫组化的方法检测了32例复发妇科恶性肿瘤患者初次手术后及二次复发灶切除术后肿瘤组织的HIF-1α及EGFR表达水平。所有患者二次手术前均经放疗。32例二次手术中有15例行腹腔镜下病灶切除及125I粒子植入,17例行开腹手术切除。结果第二次手术后肿瘤组织的HIF-1α及EGFR的阳性表达率略高于初次手术组,但无统计学意义(P>0.05)。第二次手术后肿瘤组织的HIF-1α及EGFR的强阳性表达率明显高于初次手术组(P<0.05)。10例HIF-1α及EGFR呈强阳性表达的患者预后很差。结论 HIF-1α及EGFR表达增加可降低肿瘤放射敏感性,HIF-1α及EGFR强阳性表达可作为预测放疗或125I粒子植入的疗效的指标。
Objective To investigate the expression of HIF-1α and EGFR in patients with recurrent gynecologic malignancies and its relationship with radiosensitivity. Methods The expression of HIF-1α and EGFR in tumor tissues of 32 recurrent gynecologic malignancies after primary surgery and secondary resection of tumor were detected by immunohistochemistry. All patients underwent radiotherapy before the second operation. In 32 cases of secondary surgery, 15 cases underwent laparoscopic resection and 125I seed implantation, and 17 cases underwent laparotomy. Results The positive expression rate of HIF-1α and EGFR in the tumor tissue after the second operation was slightly higher than that of the initial operation group, but there was no statistical significance (P> 0.05). The strong positive expression rate of HIF-1α and EGFR in the tumor tissue after the second operation was significantly higher than that of the initial operation group (P <0.05). 10 cases of HIF-1α and EGFR strongly positive expression of the patients with poor prognosis. Conclusion The increased expression of HIF-1α and EGFR may reduce the tumor radiosensitivity. The strong positive expression of HIF-1α and EGFR may be used as predictors of the efficacy of radiotherapy or 125I seed implantation.