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目的采用路径分析数学模型研究麻黄汤及不同配伍的发汗作用,从而探讨路径分析数学模型应用于中药复方配伍研究的合理性。方法采用均匀设计对麻黄汤处方中的药物剂量进行组合,以汗液增加百分率为指标,将方中药量与药效数据进行路径分析,描绘影响麻黄汤发汗作用的路径图。结果路径分析数学模型结果显示,麻黄和桂枝对于全方的发汗作用有较大贡献,合用后能增强发汗作用,并且显示出麻黄在全方发汗作用中的核心地位。结论路径分析数学模型能较好反应麻黄汤中药物之间的配伍关系,并能将处方中的药物与药效间的关系清晰的展现出来,体现了路径分析数学模型用于研究中药复方配伍的可行性和合理性。
OBJECTIVE: To study the effect of Mahuang Decoction and different combinations of perspiration on the basis of mathematical model of path analysis, so as to explore the rationality of applying the mathematical model of path analysis to the compatibility research of traditional Chinese medicine. Methods A uniform design was used to combine the drug doses in the recipe of Mahuang decoction. The percentage of sweat increase was taken as an index. The pathological analysis was conducted on the amount of Chinese herbs and the efficacy data to depict the pathways influencing the sweating effect of Mahuang decoction. RESULTS Path analysis The mathematical model results show that ephedra and cassia twig contribute greatly to the sweat effect of the whole party, which enhances the perspiration effect after combination and shows the central role of ephedra in the full-scale sweating effect. Conclusion The mathematical model of path analysis can better reflect the compatibility between drugs in Mahuang decoction and clearly show the relationship between the drugs and the efficacy in the prescription. The mathematical model of path analysis is used to study the compatibility of traditional Chinese medicine compound Feasibility and rationality.