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目的研究高强度聚焦超声(HIFU)联合新辅助化疗治疗乳腺癌的治疗疗效。方法选取经病理确诊为原发性乳腺癌的女性患者86例,分为HIFU治疗组36例和对照组50例。2组患者治疗后均行乳腺癌改良根治术/保乳根治术。术前用彩色多普勒超声检查监测瘤体大小变化,术后多点取材,HE染色观察形态学变化。结果经超声影像学检测HIFU治疗组临床有效率77.8%高于对照组有效率56%(P<0.05)。根据Miller&Payne分级评价标准:HIFU治疗组有效率72.2%高于对照组有效率50%(P<0.05)。结论 HIFU联合新辅助化疗治疗乳腺癌能提高单纯新辅助化疗治疗乳腺癌的疗效,是一种有效的治疗方法。
Objective To study the therapeutic effect of high intensity focused ultrasound (HIFU) combined with neoadjuvant chemotherapy on breast cancer. Methods Totally 86 female patients diagnosed as primary breast cancer by pathology were divided into HIFU treatment group (36 cases) and control group (50 cases). Two groups of patients underwent modified radical mastectomy / breast-conserving radical mastectomy. Preoperative color Doppler ultrasound examination of tumor size changes, after more drawing, HE staining observed morphological changes. Results The clinical effective rate of HIFU treatment group was 77.8% higher than that of the control group (56%) (P <0.05). According to the Miller & Payne classification criteria, the HIFU-treated group was 72.2% more effective than the control group by 50% (P <0.05). Conclusion HIFU combined with neoadjuvant chemotherapy for breast cancer can improve the efficacy of neoadjuvant chemotherapy alone in the treatment of breast cancer, which is an effective treatment.