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乙氧滴涕是广州农药厂利用生产敌百虫的废气首创合成的一种新有机氯杀虫剂。对柑桔、梨、苹果等果树和蔬菜的多种害虫有很高的药效,但它却易被生物所降解。不易在生物体内蓄积,是一种很有发展前途的杀虫剂。乙氧滴涕对小鼠的径口半数致死量为205毫克/公斤,属中等毒性,但乙氧滴涕对人体是否存在着潜在性的遗传危害并不了解。目前,普遍认为姐妹染色体单体互换(SCE)是检查致癌物或致突变物的细胞遗传学效应的一种新方法。通过它可以较准确地反映出被测物质对于染色体DNA损伤和修复的情况。本实验采用姐妹染色单体互换和染色体畸变为指标,观察乙氧滴涕诱发正常人淋巴细胞姐妹染色单体互换和染色体畸变的情况。
Oxychlorine DDT is a new organochlorine pesticide synthesized by Guangzhou Pesticide Factory using the waste gas produced by trichlorfon. On citrus, pear, apple and other fruit trees and vegetables, a variety of pests have a high efficacy, but it is easily biodegradable. Not easy to accumulate in the body, is a very promising pesticide. Oxytetrazine has a median lethal dose of 205 mg / kg for mice that are moderately toxic, but there is no understanding of the potential genetic risks of ethoxytittines to humans. Currently, it is generally accepted that Sister Chromosome Interchange (SCE) is a new way of examining the cytogenetic effects of carcinogens or mutagens. Through it can more accurately reflect the test substance for DNA damage and repair of the case. In this experiment, sister chromatid exchange and chromosomal aberration were used as indexes to observe the sister chromatid exchange and chromosomal aberration of normal human lymphocytes induced by oxychloride.