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目的利用3.0T MRI观察正常胎儿标本脊髓颈膨大最大横断面及其相对位置关系随孕周变化的规律。方法随机选取44例16~42孕周胎儿标本,行3D-T2WI和T2WI-SPC序列扫描,对所得图像三维重建,观察及测量以下参数:1颈膨大最大横断面面积:选取C4-T1脊神经区间内各椎体中心及椎间盘中心水平分别测量颈膨大横断面面积,选取最大面积,绘制最大横断面面积随孕周变化的生长曲线;2颈膨大最大横断面与椎体的相对位置关系;3比较性别间差异。结果 1颈膨大最大横断面积随孕周呈线性增加,与孕周的相关方程分别为:最大横断面积(cm2)=0.01×孕周-0.12,R2=0.91,P<0.05;2颈膨大最大横断面与椎体相对位置关系:16~28孕周胎儿颈膨大最大横断面约位于C5/6椎间盘中心水平,29~42孕周胎儿颈膨大横断面约位于C5~C5/6中心水平,此位置随孕周增加而逐渐轻度上移;3颈膨大最大横断面面积与性别没有明显统计学差异(P>0.05)。结论高场磁共振可准确反映胎儿颈膨大最大横断面积及相对位置与孕周变化的规律,建立了正常胎儿脊髓颈膨大生长发育的磁共振影像图谱及数据库。
Objective To observe the changes of maximum cross-section of cervical spinal neck and its relative position with gestational age using 3.0T MRI. Methods Forty-four fetuses with gestational age from 16 to 42 gestational weeks were randomly selected and scanned by 3D-T2WI and T2WI-SPC. The images were reconstructed by three-dimensional reconstruction. The maximal cross-sectional area of 1 neck was observed and measured. The center of each vertebral body and the center of the disc were measured neck swollen cross-sectional area, select the largest area, the maximum cross-sectional area to draw the growth curve changes with gestational age; 2 neck enlargement largest cross-section and the relative position of the vertebral body; Gender differences. RESULTS: The maximum cross-sectional area of neck enlargement increased linearly with gestational age, and the correlations with gestational age were: maximum cross-sectional area (cm2) = 0.01 × gestational week -0.12, R2 = 0.91, P <0.05; The relative position of the vertebral body and vertebrae: the largest cross-sectional area of fetal cervical enlargement at 16-28 gestational weeks was located at the center of the C5 / 6 intervertebral disc center. The fetal cervical enlargement cross-sectional area at 29-42 gestational weeks was approximately at the center of C5-5 / 6 / With the increase of gestational age and gradually increased slightly; 3 neck enlargement of the largest cross-sectional area and gender no significant difference (P> 0.05). Conclusion High-field magnetic resonance can accurately reflect the maximum cross-sectional area of fetal neck enlargement and the relative position and gestational age, and establishes the magnetic resonance imaging and database of growth and development of normal fetal cervical spinal cord.