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目的观察胃小细胞癌的临床及病理形态特点以探讨其组织发生及预后。方法对５例胃小细胞癌进行光镜观察，并对全部病例做组化及免疫组化染色，组化为Ｇｒｉｍｅｌｉｕｓ染色，标记物为ＮＳＥ，ＣｇＡ。结果胃小细胞癌组织学形态、生物学行为酷似肺小细胞癌，Ｇｒｉｍｅｌｉｕｓ染色有８０％病例瘤细胞胞浆内有嗜银颗粒，免疫组化证实其对ＮＳＥ，ＣｇＡ有一定敏感性，阳性率分别６０％，８０％。随访显示胃小细胞癌平均生存期为６个月。结论胃小细胞癌组织发生可能来源于弥散的神经内分泌细胞，属高度恶性肿瘤，预后较差。
Objective To observe the clinical and pathological features of gastric small cell carcinoma to explore its histogenesis and prognosis. Methods Five cases of gastric small cell carcinoma were observed under light microscope. Histochemical staining and immunohistochemical staining were performed on all the cases. Histochemical staining was performed with Grimelius. The markers were NSE and CgA. Results The histological morphology and biological behavior of gastric small cell carcinoma resembled that of small cell lung cancer. Eighty percent of Grimelius stained cells had cytoplasmic granules in the cytoplasm. Immunohistochemistry confirmed its sensitivity to NSE and CgA. Positive rate 60% and 80% respectively. Follow-up showed that the average survival of gastric small cell carcinoma was 6 months. Conclusion The tissue of gastric small cell carcinoma may originate from diffuse neuroendocrine cells. It is a highly malignant tumor with a poor prognosis.