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目的:研究鼻咽癌患者外周血T淋巴细胞亚群水平的特点、影响因素及临床意义。方法:运用流式细胞仪对66例鼻咽癌患者外周血T淋巴细胞亚群进行检测,并分析患者T淋巴细胞亚群变化,比较其与正常人群对照组的差异。结果:鼻咽癌患者CD4+细胞数减少(40.58±15.26%),明显低于正常对照组(P<0.01),CD8+细胞数增加,Th/Ts比值下降或倒置(0.92±0.57)。结论:鼻咽癌患者存在细胞免疫功能紊乱,检测鼻咽癌患者外周血T淋巴细胞亚群的表达对评估患者的细胞免疫功能、疾病的治疗及预后具有一定的临床意义。
Objective: To study the characteristics, influential factors and clinical significance of T lymphocyte subsets in peripheral blood of patients with nasopharyngeal carcinoma. Methods: Flow cytometry was used to detect T lymphocyte subsets in peripheral blood of 66 patients with NPC. The changes of T lymphocyte subsets in patients with NPC were analyzed. The differences between the two groups were compared with those in normal controls. Results: The number of CD4 + cells decreased (40.58 ± 15.26%) in nasopharyngeal carcinoma patients, which was significantly lower than that in normal controls (P <0.01). The number of CD8 + cells increased and the Th / Ts ratio decreased or reversed (0.92 ± 0.57). Conclusion: There are cellular immune dysfunction in patients with nasopharyngeal carcinoma. Detecting the expression of T lymphocyte subsets in peripheral blood of patients with nasopharyngeal carcinoma has certain clinical significance for evaluating cellular immune function, disease treatment and prognosis.