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目的探讨中药制剂对大鼠肝脏虫卵肉芽肿形成的影响。方法感染日本血吸虫尾蚴第7周用吡喹酮杀虫,第8周开始用低、中、高浓度中药制剂灌胃。分别在10、12、14、16周分批剖杀大鼠,取出肝脏作病理切片测量肉芽肿的大小。结果随中药浓度的增高,虫卵肉芽肿反应减轻,直径变小。结论中药制剂可以减轻血吸虫感染肝脏肉芽肿反应。
Objective To explore the effect of traditional Chinese medicine preparations on the formation of hepatic egg granuloma in rats. Methods The worms were inoculated with praziquantel for 7 weeks after infection with cercariae of schistosomiasis, and low-, medium- and high-concentration Chinese medicines were given in the 8th week. The rats were sacrificed at 10, 12, 14 and 16 weeks, and the liver was removed for pathological section to measure the size of granuloma. Results With the increase of the concentration of traditional Chinese medicine, the egg granuloma response was reduced and the diameter became smaller. Conclusion Traditional Chinese medicine preparations can alleviate the granuloma reaction of Schistosoma japonicum infection.