卵巢癌是美国妇科癌死亡中的主要原因之一。在卵巢癌的细胞遗传学研究中,多数类型为卵巢上皮细胞癌,占卵巢癌的80～90%。自从产生显带技术以来,已证实卵巢癌伴有许多染色体结构变化,其中一些研究发现非特异的染色体标记。然而,Trent和Salmon报导,卵巢癌病人使用琼脂集落系统进行研究,发现一种特异的非随机染色体异常,即6号染色体长臂缺失(6q-)。一年以后,Wake等人报导,在卵巢乳头状浆液腺癌中发现同样的染色体标记,并增加涉及14号染色体的附加特异标记。在1976年至1981年的五年期间,作者研究了72例卵巢癌 Ovarian cancer is one of the major causes of death from gynecological cancer in the United States. In the cytogenetic study of ovarian cancer, most types of epithelial ovarian cancer, accounting for 80 to 90% of ovarian cancer. Ovarian cancer has been shown to have many structural changes in the chromosomes since the banding technique was developed, some of which found non-specific chromosomal markers. However, Trent and Salmon reported that patients with ovarian cancer who studied using the agar-colony system found a specific nonrandomized chromosomal abnormality, the long arm of chromosome 6 (6q-). A year later, Wake et al. Reported that the same chromosomal signature was found in ovarian papillary serous adenocarcinoma and that additional specific markers were involved in chromosome 14. During the five years from 1976 to 1981, the authors studied 72 cases of ovarian cancer