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二巯丙磺钠是络合剂,一般引起的不良反应较轻。85年8月用此药治疗地方性慢性砷中毒时,我们发现2例有高烧、寒战及药疹等较严重的过敏反应,现报道如下。病例报告例1 女,47岁,汉族,患地方性慢性砷中毒(角化重度、色素异常重度)。自1985年8月1日起接受二巯丙磺钠治疗,第一天肌注5ml,一天三次,第二天5ml一天二次,第三天起每天一次5ml,共7天注射9针。患者于治疗期间恶心、想吐、但无皮痒及皮疹,因胃肠反应重而停治。停药后2～3天不良反应消失。8月24日再次肌注二巯丙磺钠2.5ml治疗,注后1小时,全身皮痒,约4小时后发冷、发热,检查体温39℃以上,全身皮肤(包括掌跖)潮红,
Sodium dimercaptopropane sulfonate is a complexing agent, generally cause less adverse reactions. August 1985 with this drug treatment of endemic chronic arsenic poisoning, we found two cases of high fever, chills and drug eruption and other more serious allergic reactions are reported below. Case report 1 female, 47 years old, Han, suffering from endemic chronic arsenic poisoning (severe keratosis, abnormalities of pigment). Since August 1, 1985 from the date of treatment of sodium dimercaptopropane sulfonate, intramuscular injection of the first day of 5ml, three times a day, the second day of 5ml twice a day, the third day once daily 5ml, a total of 7 days 9 injections. Patients during treatment nausea, vomiting, but no itchy skin and rash, re-stop due to gastrointestinal reactions. 2 to 3 days after stopping the adverse reactions disappear. August 24 once again intramuscular injection of sodium dimercaptopropane sulfonate 2.5ml treatment, note 1 hour after the whole body itchy, about 4 hours after the chills, fever, check the body temperature above 39 ℃, systemic skin (including palmoplantar) flushing,