论文部分内容阅读
目的 观察欧必亭 (Tropisetron)预防化疗所致恶心呕吐的疗效和不良反应 ,并与康泉(Kytril)进行对比研究。方法 采用临床随机自身对照方法 ,将 34例接受联合化疗 (19例含顺铂 )的患者随机分为AB、BA两组 ,均接受两个周期相同方案的化疗。AB组第 1周期用欧必亭 ,第 2周期用康泉 ;BA组第 1周期用康泉 ,第 2周期用欧必亭。结果 化疗第 1天欧必亭组止吐的有效率为97.1% ,中位呕吐次数为 4.5次 ;康泉的有效率为 94.1% ,中位呕吐次数为 3次 ,经统计学处理 ,两组差异无显著性。对迟发性呕吐和副作用也进行了对比 ,欧必亭和康泉差异亦无显著性。结论 欧必亭为预防化疗所致恶心呕吐的有效药物 ,其不良反应轻微。
Objective To observe the efficacy and adverse reactions of Tropisetron in the prevention of nausea and vomiting caused by chemotherapy, and compare it with Kytril. Methods Thirty-four patients who received combination chemotherapy (19 patients with cisplatin) were randomly divided into two groups, AB and BA, and received two cycles of the same regimen of chemotherapy. The first cycle of the AB group was used with Obi-ting and the second cycle with Kangquan; the first cycle of the BA group was Kangquan, and the second cycle was with Obi-ting. Results On the first day of chemotherapy, the effective rate of antiemetic in the Oberoi group was 97.1%, the median frequency of vomiting was 4.5; the effective rate of Kangquan was 94.1%, and the median number of vomiting was 3, after statistical analysis, the difference between the two groups was not Significant. Delayed vomiting and side effects were also compared, and there was no significant difference between Eubitine and Kangquan. Conclusion Obibutine is an effective drug for preventing nausea and vomiting caused by chemotherapy. Its adverse reactions are mild.