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目的观察胶体果胶铋干混悬剂在幽门螺杆菌(HP)阳性消化性溃疡中的临床疗效及应用安全性。方法选取2014年8月—2016年10月沈阳二四五医院消化内科收治的70例HP阳性消化性溃疡患者,随机分为对照组(35例,给予三联疗法+胶体果胶铋胶囊)和观察组(35例,给予三联疗法+胶体果胶铋干混悬剂),比较两组HP清除率和不良反应发生情况。计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组HP清除率(94.3%)明显高于对照组(68.6%),差异有统计学意义(P<0.05);观察组不良反应发生率2.9%,对照组不良反应发生率5.7%,两组比较差异无统计学意义(P>0.05)。结论胶体果胶铋干混悬剂能够有效清除HP感染,且安全性高。
Objective To observe the clinical efficacy and safety of colloidal pectin bismuth suspension in patients with Helicobacter pylori (HP) -positive peptic ulcer. Methods Seventy patients with HP-positive peptic ulcer admitted to Department of Gastroenterology, Shenyang 245 Hospital from August 2014 to October 2016 were randomly divided into control group (35 cases treated with triple therapy plus colloidal bismuth gel capsule) and observation Group (35 cases, given triple therapy + colloidal pectin bismuth suspension), compared two groups of HP clearance rate and adverse reactions. Count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The clearance rate of HP in observation group (94.3%) was significantly higher than that in control group (68.6%), the difference was statistically significant (P <0.05). The adverse reaction rate in observation group was 2.9% and that in control group was 5.7% There was no significant difference between the two groups (P> 0.05). Conclusion Colloidal pectin bismuth suspension can effectively remove HP infection and is safe.