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目的观察乌司他丁联合血必净注射液治疗急性百草枯中毒的疗效。方法将2010年1月~2013年1月在本院急诊科住院治疗的急性百草枯中毒86例患者随机分为两组,对照组43例给予常规催吐、洗胃、导泻,清洁灌肠,大量补液,利尿,维生素C、E,保护脏器功能及血液灌流治疗,实验组43例在对照组基础上加用乌司他丁联合血必净注射液治疗,对比观察两组患者发生肺纤维化、多器官功能障碍综合征(MODS)及病死率之间的差异。结果与对照组相比,实验组发生肺纤维化、MODS的人数少,病死率低,差异有统计学意义(P<0.05)。结论乌司他丁联合血必净注射液在治疗急性百草枯中毒时能够有效改善患者重要脏器功能,降低肺纤维化及MODS的发生率,病死率下降,是临床上治疗急性百草枯中毒的有效方法之一。
Objective To observe the curative effect of ulinastatin combined with Xuebijing injection on acute paraquat poisoning. Methods A total of 86 acute paraquat poisoning patients hospitalized in the emergency department of our hospital from January 2010 to January 2013 were randomly divided into two groups. The control group received routine emetic, gastric lavage, catharsis, cleansing enema, Rehydration, diuretic, vitamin C, E, protection of organ function and hemoperfusion therapy. The experimental group was treated with ulinastatin combined with Xuebijing injection in 43 cases in the experimental group. , Multiple organ dysfunction syndrome (MODS) and mortality. Results Compared with the control group, the incidence of pulmonary fibrosis and MODS in the experimental group was small and the mortality was low, the difference was statistically significant (P <0.05). Conclusion Ulinastatin combined with Xuebijing injection can effectively improve the function of vital organs in patients with acute paraquat poisoning, reduce the incidence of pulmonary fibrosis and MODS, and reduce the mortality. It is a clinical treatment of acute paraquat poisoning One of the effective ways.