目的 设计合成系列(?)酮多羟基衍生物,初步研究其体外抗氧化活性的构效关系。方法 以多甲氧基取代的邻甲氧基苯甲酸为起始原料,酰氯化后,与多甲氧基苯发生F-C反应得到相应的二苯甲酮中间体,再环合、脱甲基化得到多羟基(?)酮。结果 得到8个(?)酮多羟基衍生物,经IR、H-NMR等确证其结构。结论 初步药理实验表明,抗氧化活性与羟基的相对位置有关。 OBJECTIVE To design a series of polyhydroxy derivatives of ketones and to study the structure-activity relationship of their antioxidant activity in vitro. Methoxybenzoic acid substituted with polymethoxy was used as starting material. After chlorination, FC reaction with polymethoxybenzene gave the corresponding benzophenone intermediate, cyclization and demethylation Get polyhydroxy ketone. The results obtained eight (?) Ketone polyhydroxy derivatives confirmed by IR, H-NMR and other structures. Conclusion Preliminary pharmacological experiments show that the antioxidant activity and the relative position of hydroxyl.