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本文观察了25倒铂冶炼人员的健康状况。铂复合盐引起的主要综合征是:哮喘、支气管炎、粘膜卡他及皮炎。根据以上症状将患者分为三组:Ⅰ、明显症状组;Ⅱ、一般症状组;Ⅲ、无症状接触者。试验室检查项目:以氯铂酸铵为抗原的皮肤点刺试验,血清中总IgE及铂特异性IgE测定(用放射免疫吸附试验及放射变应原吸附试验)。25例中皮试阳性者8例;血清总IgE阳性者12例,各组间阳性率无显著性差别。铂特异性IgE水平及阳性率,Ⅰ组明显高于Ⅱ、Ⅲ组及正常人对照;其均值依次为781.39±159.47,315.98±68.22,413.8±93.99,129.8±30.5CPM;各组阳性率依次为88％,36％,33％。以上结果表明,铂特异性IgE测定在本病病因学诊断方面是有用的一种体外检查技术。
This article examined the health of 25 inverted platinum smelters. The main syndromes caused by platinum complex salts are: asthma, bronchitis, mucocutal and dermatitis. According to the above symptoms, the patients were divided into three groups: Ⅰ, obvious symptom group; Ⅱ, general symptom group; Ⅲ, asymptomatic contact. Laboratory test items: skin prick test with ammonium chloroplatinate as antigen, determination of total IgE and platinum-specific IgE in serum (using radioimmunoassay and radiolabeled allergen adsorption). 25 cases of positive skin test in 8 cases; serum total IgE positive in 12 cases, the positive rate between the groups no significant difference. The level of IgE and the positive rate of platinum-specific IgE in group Ⅰ were significantly higher than those in group Ⅱ and Ⅲ and normal controls, with mean values of 781.39 ± 159.47, 315.98 ± 68.22, 413.8 ± 93.99 and 129.8 ± 30.5 CPM respectively; the positive rates of each group were 88%, 36%, 33%. The above results indicate that the platinum-specific IgE assay is a useful in vitro assay for the etiological diagnosis of this disease.