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目的了解铜绿假单胞菌(PAE)临床感染特点和耐药特性,为医院感染的监测与控制提供依据。方法采用法国生物梅里埃公司的API鉴定系统及VITEK2系统进行细菌鉴定,用K-B纸片扩散法进行药敏试验,用WHONET 5.4软件分析PAE的耐药性。结果10年来共分离出2479株PAE,主要来源于病房的呼吸道标本,其对23种抗菌药物的耐药率逐年上升,只有美罗培南、亚胺培南、头孢他啶和环丙沙星的耐药率<30%,多重耐药PAE共有188株,主要分布在重症监护病房、呼吸内科。结论PAE的耐药性已十分严重,必须进行严密监控,以预防PAE导致的医院感染暴发流行。
Objective To understand the characteristics and drug resistance of clinical isolates of Pseudomonas aeruginosa (PAE) and provide basis for the monitoring and control of nosocomial infections. Methods Bacterial identification was carried out by using the API identification system and VITEK2 system of French bioMérieux. The drug susceptibility test was conducted by K-B disk diffusion method. The drug resistance of PAE was analyzed by WHONET 5.4 software. Results A total of 2479 PAEs were isolated in the past 10 years, mainly from the respiratory specimens of the ward. The resistance rate of 23 antibacterials increased year by year, only the rates of resistance to meropenem, imipenem, ceftazidime and ciprofloxacin <30%, multi-resistant PAE a total of 188 strains, mainly in intensive care unit, respiratory medicine. Conclusion The drug resistance of PAE has been very serious and must be closely monitored to prevent the outbreak of nosocomial infections caused by PAE.