自杀基因治疗肿瘤近年来在国内外研究较多并已取得了明显的疗效。本文就近年来有关的进展 ,从自杀基因治疗作用体系机制及其旁观者效应、增强自杀基因转导效率方面的载体应用和肿瘤特异性靶向性转导、自杀基因与免疫系统反应的关系、自杀基因与靶向性放射性核素治疗、免疫因子及自杀基因 3种方法的联合应用等进行综述 Suicide gene therapy in recent years at home and abroad more research and has achieved significant results. This article in recent years, the progress of the suicide gene therapy mechanism and its bystander effect, enhance the efficiency of suicide gene transduction vector applications and tumor-specific targeted transduction, the relationship between suicide genes and the immune system, suicide Gene and targeted radionuclide therapy, immune factors and suicide gene combination of three methods are reviewed