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目的 分析泌尿系结石腔镜手术后尿源性脓毒血症发生的原因及防治方式，总结防治策略。方法 选择84例泌尿系结石腔镜手术后尿源性脓毒血症患者作为研究对象，结合防治举措的差异实施分组，对照组和观察组分别进行常规防治和综合性防治，干预后对相关数据进行分析。结果 观察组治疗总有效率（95.24%）明显高于（71.43%）（P＜0.05）。观察组患者的身体指标积分、不良症状积分均优于对照组（P＜0.05）。观察组的生活质量评分、心理健康评分高于对照组，焦虑评分和抑郁评分低于对照组（P＜0.05）。结论 针对泌尿系结石腔“,”Objective To analyze the causes， prevention and treatment of urogenic sepsis after endoscopy for urinary calculi， and summarize the prevention and treatment results. Methods A total of 84 patients with urogenic sepsis after urolithiasis endoscopic surgery were selected as the research objects. Combined with the difference in prevention and treatment measures， they were divided into control group and observation group， respectively， for routine prevention and treatment and comprehensive prevention and treatment， and the data were analyzed after intervention. Results The total effective rate of observation group and control group was 95.24% and 71.43% respectively. The body index scores and adverse symptom scores of the two patients were analyzed， and the scores of the observation group were better than those of the control group (P＜0.05). The scores of quality of life and mental health in the observation group were higher than those in the control group， and the scores of anxiety and depression were lower than those in the control group (P＜0.05). Conclusion The comprehensive prevention and treatment of urogenic sepsis after endoscopic urolithiasis surgery can improve the quality of life of patients.