磷酸肌醇(PI)的转化在许多刺激物如生长因子、激素等诱导的细胞内信息传递途径中起重要作用。磷脂酶 C(PLC)则控制 PI 转化的速率,催化磷脂酰肌醇4,5-二磷酸酯(PIP_2)水解生成1,4,5-三磷酸肌醇酯(IP_3)和二酰基甘油酯(DAG)。PIP_2刺激细胞内Ca~(2+)的释放,而 DAG 则激活蛋白激酶 C。Ca~(2-)浓度的增加和蛋白激酶 C 的激活会引起一系列反应,最终导致 DNA 的合成和细 Phosphoinositide (PI) conversion plays an important role in the intracellular signaling pathways induced by many stimuli such as growth factors, hormones and the like. Phospholipase C (PLC) controls the rate of PI conversion and catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP_2) to produce inositol 1,4,5-trisphosphate (IP_3) and diacylglycerides ( DAG). PIP-2 stimulates the release of intracellular Ca~(2+), while DAG activates protein kinase C. Increased Ca~(2-) concentration and activation of protein kinase C cause a series of reactions that eventually lead to DNA synthesis and fine