论文部分内容阅读
目的:研究类风湿性关节炎(RA)患者血清血管内皮生长因子(VEGF)与炎症指标的相关性。方法:随机选取2014年1月至2015年12月我院收治RA患者59例,包括32例RA活动期患者(RA活动期组)与27例RA缓解期患者(RA缓解期组),另抽取同期30例健康体检者作为对照组。应用双抗体夹心酶联免疫吸附法检测三组血清VEGF水平及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α),用免疫比浊法检测C-反应蛋白(CRP)水平,并采用Pearson相关分析RA患者血清VEGF水平与三项炎性因子之间的相关性。结果:三组血清VEGF以及CRP、IL-6、TNF-α整体比较,差异均有统计学意义(均P<0.05),且以上各指标在RA活动期组、RA缓解期组、对照组中依次降低,两两比较差异均有统计学意义(均P<0.05)。RA患者的血清VEGF与CRP、IL-6、TNF-α水平均呈正相关关系(r=0.556、r=0.517、0.682,均P<0.05)。结论:血清VEGF及CRP、IL-6、TNF-α在RA患者病理改变过程中均表达过度,且VEGF与炎性因子间存在协同相关作用。
Objective: To investigate the correlation between serum vascular endothelial growth factor (VEGF) and inflammation in patients with rheumatoid arthritis (RA). Methods: Fifty-nine patients with RA in our hospital from January 2014 to December 2015 were randomly selected, including 32 patients with RA active stage (RA active group) and 27 patients with RA remission (RA remission group) The same period, 30 cases of healthy people as a control group. Serum levels of VEGF, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by sandwich enzyme linked immunosorbent assay (ELISA) ) Levels, and Pearson correlation analysis of RA patients with serum VEGF levels and three inflammatory factors between the correlation. Results: The levels of serum VEGF, CRP, IL-6 and TNF-α in the three groups were significantly different (all P <0.05), and the above indexes were significantly different between RA active group, RA remission group and control group Followed by reduction, any difference was statistically significant (P <0.05). The serum levels of VEGF in RA patients were positively correlated with the levels of CRP, IL-6 and TNF-α (r = 0.556, r = 0.517,0.682, all P <0.05). Conclusion: The levels of serum VEGF, CRP, IL-6 and TNF-α are overexpressed in the pathogenesis of RA, and there is a synergistic correlation between VEGF and inflammatory cytokines.