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INK4a-ARF基因是新近发现的抑癌基因,包含两个重叠基因:INK4a和ARF,编码产物p16INK4a和p14ARF蛋白,分别对cyclinD-CDK4-pRb-E2F和MDM2-p53通路具有关键性调控功能,且在大部分恶性肿瘤中缺失表达,其功能失活的机制主要包括该基因的缺失、突变和甲基化。但在妇科肿瘤如宫颈癌及外阴癌中p16INK4a和p14ARF蛋白过表达,提示INK4a-ARF基因在妇科肿瘤发生发展中所起的作用可能与其在其他肿瘤中所起的作用不同,将成为妇科肿瘤检测与预后判断的标志性基因之一。就INK4a-ARF基因与妇科肿瘤关系的研究进展综述。
The INK4a-ARF gene is a recently discovered tumor suppressor gene that contains two overlapping genes, INK4a and ARF, encoding the products p16INK4a and p14ARF, which have key regulatory roles for the cyclinD-CDK4-pRb-E2F and MDM2-p53 pathways, respectively In most malignant tumors, the mechanism of inactivation mainly includes the deletion, mutation and methylation of the gene. However, the overexpression of p16INK4a and p14ARF in gynecological tumors such as cervical cancer and vulvar cancer suggest that the role of INK4a-ARF in the development of gynecologic tumors may be different from that of INK4a-ARF in other tumors and become a gynecological tumor detection One of the landmark genes with prognosis. Review on the Progress of Research on the Relationship between INK4a-ARF Gene and Gynecologic Oncology.