血脑屏障(BBB)的基本结构是脑毛细血管内皮细胞间的紧密连接。这方面的研究较多,具有重要意义。本文概要综述关于BBB与BBB开放的研究简况。 一、BBB的概念过去认为,BBB系脉络丛、脑毛细血管壁与脑组织之间的结构,包括血管内皮细胞、基膜、神经胶质细胞突起。近十多年来,由于电子显微镜和生物酶标技术的进展,对BBB及其部位所在提供了重要资料,BBB的概念也远远超出原先的含义。将辣根过氧化酶(HRP)、铁蛋白等示踪剂注入血管后,可见其受阻于内皮细胞问的紧密连接处,不能进入脑组织。如果用另一种方式将上述示踪剂直接注入脑组织或脑脊液中,发现它们不是在神经胶质细胞突起或基膜处受阻,也是被毛细血管内皮细胞及其紧密连接所阻挡,不能进入毛细血管腔,上述结果提示脑毛细血管内皮细胞及其间的紧密连接是BBB的基本结构。而神经胶质细胞突起和基膜并非真正的通透性屏障,它们可能对BBB的通透性起一定辅助作用。脑毛细血管与一般的毛细血管相比有所不同,内皮细胞无窗孔,缺乏吞饮小泡,但细胞间有紧密连 The basic structure of the blood-brain barrier (BBB) ​​is the tight junction between brain capillary endothelial cells. More research in this area is of great significance. This article provides an overview of the research on the openness of BBB and BBB. First, the concept of BBB In the past that BBB Department choroid plexus, the structure between the brain capillary wall and brain tissue, including vascular endothelial cells, basement membrane, glial processes. In the recent ten years, due to the progress of electron microscopy and bio-enzyme labeling technology, the BBB and its parts provide important information. The concept of BBB goes far beyond the original meaning. The horseradish peroxidase (HRP), ferritin and other tracer injected into the blood vessels, showing its blocked by endothelial cells asked close connection, can not enter the brain. If the tracer was otherwise injected directly into brain tissue or cerebrospinal fluid, it was found that they were not blocked at glial cell projections or basement membrane, blocked by capillary endothelial cells and their tight junctions and could not enter the capillary Vascular lumen, the above results suggest that brain capillary endothelial cells and the tight junction between them is the basic structure of BBB. While glia and basement membranes are not truly permeable barriers, they may play a supporting role in BBB permeability. Brain capillaries compared with the general capillaries are different, no endothelial cells, lack of swallow drinking vesicles, but cells are closely linked