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目的研究2型糖尿病患者骨保护素(osteoprotegerin,OPG)水平与动脉粥样硬化(atherosclerosis,AS)的相关性。方法选取长沙市中心医院内分泌科88例2型糖尿病患者,根据颈动脉内中膜厚度(intima-media thickness,IMT)分为AS组和非AS组,另选同期医院体检中心健康者40名为对照组,分别测定血浆OPG水平以及血液生化指标。结果 2型糖尿病AS组OPG水平高于非AS组,两组均高于正常对照组;OPG水平与颈动脉IMT、空腹血糖、糖化血红蛋白呈正相关;糖化血红蛋白、低密度脂蛋白胆固醇(low-density lipoprotein-cholesterol,LDL-C)、OPG及年龄是影响颈动脉IMT的相关因素。结论在2型糖尿病中,OPG升高与动脉粥样硬化密切相关,有必要在病程早期检测OPG,并及早进行干预,降低糖尿病动脉粥样硬化风险。
Objective To study the correlation between osteoprotegerin (OPG) level and atherosclerosis (AS) in type 2 diabetic patients. Methods 88 patients with type 2 diabetes mellitus in Department of Endocrinology, Central Hospital of Changsha were divided into AS group and non-AS group according to carotid intima-media thickness (IMT). Another 40 healthy subjects Control group, respectively, the level of plasma OPG and blood biochemical indicators. Results The level of OPG in type 2 diabetic AS group was higher than that in non-AS group, and both groups were higher than those in normal control group. The level of OPG was positively correlated with carotid IMT, fasting blood glucose and glycosylated hemoglobin. HbA1c, low-density lipoprotein cholesterol lipoprotein-cholesterol, LDL-C), OPG and age are related factors of carotid IMT. Conclusions In type 2 diabetes, elevated OPG is closely related to atherosclerosis. It is necessary to detect OPG early in the course of the disease and to intervene early to reduce the risk of diabetic atherosclerosis.