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目的:探讨邯郸农村地区30岁及以上人群中常见致盲性眼底病的患病率及影响因素。方法:采用队列研究设计，2006年在河北省邯郸市农村地区30岁及以上人群中抽取6 830例研究对象，随访6年，观察致盲性眼底病的患病率及发病率。采用多因素logistic回归模型分析常见致盲性眼底病发病的危险因素。结果:前瞻性队列研究。2006年，6 830人参与基线调查，男3 163人（46.31%），女3 667人（53.69%），年龄30~97（52.3±12.2）岁；其中患有常见慢性非传染性疾病（慢病）者3 435例，患病率为50.29%。此外，患有常见致盲性眼底病1 250例，患病率为18.30%。4 118人基线不患有常见致盲性眼底病，并参与了第6年随访。6年中，共新发致盲性眼病247例，9%（171/1 899）的慢病患者新发常见致盲性眼底病，而基线非慢病者中仅3.42%（76/2 219）新发常见致盲性眼底病（χn 2=56.504，n P<0.001）。常见致盲性眼底病的发病率与年龄有关，多因素回归分析结果显示，年龄（n OR=1.045，95n %CI：1.028~1.062，n P<0.001）、眼压（n OR=1.064，95n %CI：1.014~1.116，n P=0.011）和基线患有慢病（n OR=1.749，95n %CI：1.288~2.375，n P<0.001）是常见致盲性眼底病的危险因素。计算上述3个危险因素对模型的解释比例，结果显示，年龄、眼压和慢病对模型的解释比例分别为0.436、0.084和0.511。n 结论:邯郸地区30岁及以上人群中常见致盲性眼底病的患病率较高，2006至2012年，每年约有1.5%的慢病患者新发常见致盲性眼底病；慢病增加了致盲性眼底病的患病风险，且作用较年龄和眼压更强。“,”Objective:To explore the prevalence and risk factors of common blinding ocular diseases in the population aged 30 years and above in rural areas of Handan City from 2006 to 2012.Methods:A cohort study with 6 830 subjects from rural areas of Handan City, Hebei Province was designed and conducted. The follow-up duration was 6 years, and the prevalence and incidence of common blinding diseases were evaluated. Logistic regression was used to explore the influencing factors of common blinding ocular diseases.Results:In 2006, 6 830 people participated in the baseline survey. There were 3 163 (46.31%) males and 3 667 (53.69%) females. The average age was (52.3±12.2) years (range, 30 to 97 years). There were 3 435 subjects who had common chronic systematic diseases, with a prevalence of 50.29%. In addition, 1 250 people suffered from common blinding ocular diseases, and the prevalence was 18.30%. There were 4 118 subjects without common blinding ocular diseases at baseline who participated in the six-year follow-up, during the 6-year follow-up, 247 participants developed common blinding ocular diseases. 9% (171/1 899) of patients with chronic systematic diseases developed common blinding ocular diseases, while only 3.42% (76/2 219) of normal subjects developed common blinding ocular diseases, with a statistically significant difference (χn 2=56.504, n P<0.001). The incidence of common blinding ocular diseases was age-dependent. Multivariate regression analysis showed that age (n OR=1.045, 95%n CI: 1.028-1.062, n P<0.001), intraoccular pressure (IOP) (n OR=1.064, 95% n CI: 1.014-1.116, n P=0.011) and baseline chronic diseases (n OR=1.749, 95% n CI: 1.288-2.375, n P<0.001) were risk factors for common blinding ocular diseases. Moreover, the contribution of age, IOP and chronic systematic diseases to the model was 0.436, 0.084 and 0.511, respectively.n Conclusions:The prevalence of common blinding ocular diseases among people over 30 years old in Handan is relatively high. From 2006 to 2012, about 1.5% patients of chronic systematic diseases developed common blinding ocular diseases each year. Moreover, chronic systematic diseases increase the risk of blinding ocular diseases sharply, and the effect is stronger than age and intraocular pressure.