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目的:探讨人类染色体端粒酶RNA(hTERC)在宫颈病变中的表达。方法:荧光原位杂交(FISH)法检测8例宫颈癌,28例CINⅢ,10例CINⅡ,6例CINⅠ及25例慢性宫颈炎组织中hTERC的表达情况。结果:hTERC在慢性宫颈炎组织、CINⅠ、CINⅡ、CINⅢ及宫颈癌中的阳性表达率分别为12.0%、16.7%、20.0%、71.4%和100.0%,与病变程度呈正相关(r=0.631,P<0.01),各组间差异有统计学意义(P<0.05)。结论:hTERC的阳性表达率与宫颈病变程度密切相关,提示其在宫颈癌的发生发展中起着重要作用。
Objective: To investigate the expression of human telomerase RNA (hTERC) in cervical lesions. Methods: The expression of hTERC in 8 cases of cervical cancer, 28 cases of CIN Ⅲ, 10 cases of CIN Ⅱ, 6 cases of CIN Ⅰ and 25 cases of chronic cervicitis were detected by fluorescence in situ hybridization (FISH). Results: The positive rates of hTERC in chronic cervicitis, CINⅠ, CINⅡ, CINⅢ and cervical cancer were 12.0%, 16.7%, 20.0%, 71.4% and 100.0%, respectively, which were positively correlated with the degree of lesion (r = 0.631, P <0.01). The differences among the groups were statistically significant (P <0.05). Conclusion: The positive rate of hTERC is closely related to the degree of cervical lesions, suggesting that hTERC plays an important role in the occurrence and development of cervical cancer.