以往报道,钙拮抗药与抑制药合用可引起严重生理反应。在外科手术中,维拉帕米常与局麻药并用,由于维拉帕米和局麻药分别阻滞钙、钠通道,且维拉帕米本身亦有局麻作用,因此,理论上两药相互作用可能使局麻药毒性增加。为验证这一设想,本文作者以小鼠进行实验研究。选用8～12周,体重25～35g的雌性小鼠,分成4组。试验组Ⅰ:76只小鼠于腹膜腔内注射维拉帕米(1.5mg/kg),之后即给LD_(50)的利多卡因(133.1mg/kg)或布比卡因(71.2mg/kg)。试验组Ⅱ:80只小鼠接受氯化钙(100mg/kg)和维拉帕米(1.5mg/kg)后,同样立即给LD_(50)的利多卡因或布比卡因。试 Previous reports, calcium antagonists and suppressive drugs can cause serious physiological reactions. In surgery, verapamil and local anesthetics often used, because verapamil and local anesthetics block calcium and sodium channels, and verapamil itself also has the role of local anesthetic, therefore, in theory, the two drugs The role of local anesthetic toxicity may increase. To test this hypothesis, the authors conducted experimental studies in mice. Selection of 8 to 12 weeks, weighing 25 ~ 35g of female mice were divided into 4 groups. Test Group I: 76 mice were injected with verapamil (1.5 mg / kg) into the peritoneal cavity, followed by LD 50 lidocaine (133.1 mg / kg) or bupivacaine (71.2 mg / kg). Trial Group II: Immediately after administration of calcium chloride (100 mg / kg) and verapamil (1.5 mg / kg) to 80 mice, lidocaine LD50 or bupivacaine was also given immediately. test