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上海交通大学医学院健康科学研究所科研人员发现临床条件下微环境外泌蛋白SFRP2/WNT16B导致癌细胞获得性耐药中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所孙宇教授领衔的研究组在临床治疗本身引发微环境因素造成癌细胞获得性耐药研究中取得新发现。研究揭示了基因毒化疗药物可以激发细胞非自主性分泌表型,以及作为基质细胞释放至微环境中
Shanghai Jiaotong University School of Medicine Institute of Health Sciences found that under clinical conditions, microenvironment exoprotein SFRP2 / WNT16B lead to acquired resistance of cancer cells Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences / Shanghai Jiao Tong University School of Medicine Institute of Health Sciences Professor Sun Yu The lead team made new discoveries in the study of acquired resistance to cancer cells caused by microenvironmental factors in clinical therapy itself. Research reveals that genotoxic chemotherapy drugs can stimulate involuntary cellular secretion of phenotypes as well as release of stromal cells into the microenvironment