论文部分内容阅读
目的:探讨细胞凋亡在星形细胞瘤中的作用及其与p53、Fas和Fas配体(Fas ligand,FasL)的关系。方法:对43例星形细胞瘤的标本分别进行HE染色,TUNEL及免疫组化分别标记p53,Fas和FasL。结果:高级别肿瘤和低级别肿瘤间的凋亡无显著差异(P>0.05)。高级别星形细胞瘤的p53,Fas和FasL的表达均显著高于低级别肿瘤(P均<0.05)。结论:突变型p53可作为评价星形细胞瘤生物学行为的参考指标。与低级别星形细胞瘤相比,高级别肿瘤中的细胞凋亡受到了抑制,且Fas与FasL的过表达对细胞凋亡可产生明显影响。
Objective: To investigate the role of apoptosis in astrocytoma and its relationship with p53, Fas and Fas ligand. Methods: 43 cases of astrocytomas were stained with HE, TUNEL and immunohistochemistry were used to label p53, Fas and FasL respectively. Results: There was no significant difference in apoptosis between high-grade tumors and low-grade tumors (P> 0.05). The expression of p53, Fas and FasL in high grade astrocytomas were significantly higher than those in lower grade tumors (all P <0.05). Conclusion: Mutant p53 can be used as a reference to evaluate the biological behavior of astrocytomas. Compared with low-grade astrocytomas, apoptosis in high-grade tumors is inhibited, and overexpression of Fas and FasL can have a significant effect on apoptosis.