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目的:通过短期胰岛素强化治疗手段,分析2型糖尿病患者的胰岛β功能在治疗前后的变化,旨在进一步提高与优化2型糖尿的临床效果与质量。方法:从本院自2013年9月到2014年8月收治的2型糖尿病的患者中选取80例患者作为本次治疗研究对象,以15天为治疗周期,对患者采取胰岛素强化治疗措施,并以高葡萄糖钳夹技术对患者治疗前后的胰岛β细胞功能进行评估。结果:80例糖尿病患者患者经过本次短期胰岛素强化治疗后胰岛β细胞功能都有所改善,在治疗前,2型糖尿病患者的第一时相胰岛素分泌为93±11mU/L,第二时相胰岛素分泌为32±10mU/L,最大时相胰岛素分泌为38±13mU/L,与正常人胰岛素分泌水平相比处于明显偏低的状态,但经本次短期胰岛素强化治疗后,患者的第一、第二以及最大时相的胰岛素分泌分别提升至129±31mU/L、57±11mU/L、48±9mU/L,治疗后患者胰岛素分泌水平与治疗前相比都取得较为显著的提高,具有统计学意义(P<0.05)。结论:短期胰岛素强化治疗在临床应用过程中能够对2型糖尿病患者的胰岛β细胞功能产生一定的改善效果,让患者不同时相胰岛素分泌水平有所提高,值得在临床应用中大范围推广。
OBJECTIVE: To analyze the changes of pancreatic β function in patients with type 2 diabetes before and after treatment by means of short-term intensive insulin therapy in order to further improve and optimize the clinical effect and quality of type 2 diabetes. Methods: From the hospital from September 2013 to August 2014 admitted to patients with type 2 diabetes, 80 patients were selected as the treatment of the object of this study, 15 days for the treatment cycle, patients with intensive insulin therapy and High glucose clamp technique was used to assess the function of pancreatic β-cells before and after treatment. Results: The function of pancreatic β-cells was improved in 80 patients with diabetes mellitus after this short-term intensive insulin treatment. Before treatment, the first phase insulin secretion in type 2 diabetic patients was 93 ± 11 mU / L. The second phase Insulin secretion of 32 ± 10mU / L, the maximum phase of insulin secretion of 38 ± 13mU / L, compared with the normal level of insulin secretion was significantly lower state, but after this short-term intensive insulin treatment, the patient’s first , Insulin secretion increased to 129 ± 31mU / L, 57 ± 11mU / L and 48 ± 9mU / L in the second and the largest phases, respectively. Compared with those before treatment, insulin secretion increased significantly, with Statistical significance (P <0.05). Conclusion: Short-term intensive insulin therapy can improve pancreatic β-cell function in patients with type 2 diabetes mellitus during clinical application, and improve the level of insulin secretion in different phases of patients. It is worth to be extended in clinical application.