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目的探讨冠心病合并非酒精性脂肪性肝病(NAFLD)患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值变化及临床意义。方法收集冠心病患者112例作为研究对象,根据是否合并NAFLD分为冠心病NAFLD组(n=52)和单纯冠心病组(n=60),另选择同期健康志愿者50例作为对照组。采用酶联免疫吸附法(ELISA)测定血清Ghrelin、obestatin水平。根据冠脉造影结果,采用Gensini积分评估冠脉病变程度。结果冠心病NAFLD组、单纯冠心病组患者的Ghrelin/obestatin比值显著低于对照组;冠心病NAFLD组患者的Gensini积分明显高于单纯冠心病组,差异均有统计学意义(P<0.05)。冠心病NAFLD组患者的Ghrelin/obestatin比值与Gensini积分呈负相关(r=-0.59,P<0.05)。结论冠心病合并NAFLD患者的Ghrelin/obestatin比值与冠状动脉病变程度密切相关。Ghrelin/obestatin比值在预测冠心病合并NAFLD中有一定的辅助参考价值。
Objective To investigate the changes of Ghrelin / obestatin in patients with coronary heart disease complicated with non-alcoholic fatty liver disease (NAFLD) and its clinical significance. Methods One hundred and twelve patients with CHD were enrolled in this study. According to whether NAFLD was combined with NAFLD or not, 50 healthy volunteers were selected as the control group. Serum Ghrelin and obestatin levels were measured by enzyme-linked immunosorbent assay (ELISA). According to the result of coronary angiography, Gensini score was used to evaluate the degree of coronary artery lesion. Results The Ghrelin / obestatin ratio in patients with NAFLD and simple coronary heart disease was significantly lower than that of the control group. The Gensini score of NAFLD patients with coronary heart disease was significantly higher than that of patients with coronary heart disease (P <0.05). The Ghrelin / obestatin ratio in patients with NAFLD was negatively correlated with Gensini score (r = -0.59, P <0.05). Conclusion The Ghrelin / obestatin ratio in patients with coronary heart disease and NAFLD is closely related to the severity of coronary artery disease. Ghrelin / obestatin ratio in the prediction of coronary heart disease with NAFLD has some auxiliary reference value.