论文部分内容阅读
目的分析肾移植前后持续性血液透析患者颈动脉僵硬度的变化,探讨最大剪切率(SRmax)与颈动脉僵硬度的关系。方法选取移植肾患者31例(移植肾组)、维持性血液透析的终末期肾病患者31例(终末期肾病组)及年龄、性别相匹配的健康成人84例为对照组。应用超声分别测量各组左右侧颈动脉脉搏波传导速度(PWV)和左右侧颈动脉SRmax,分析PWV与SRmax的关系。结果 (1)终末期肾病组和移植肾组患者左右侧颈动脉PWV均大于对照组(均P<0.05),左侧颈动脉SRmax均小于对照组(均P<0.05)。终末期肾病组和移植肾组左右侧颈动脉PWV比较差异均无统计学意义。3组右侧颈动脉SRmax比较差异均无统计学意义。(2)终末期肾病组中,右侧颈动脉PWV大于左侧(P<0.05);对照组和移植肾组中,左右侧颈动脉PWV比较差异均无统计学意义。终末期肾病和移植肾组中,左右侧颈动脉SRmax比较差异无统计学意义;对照组中,左侧颈动脉SRmax大于右侧(P<0.05)。(3)左右侧颈动脉PWV与年龄、收缩压及舒张压呈正相关,与SRmax呈线性负相关(均P<0.05)。结论肾移植患者颈动脉僵硬度与SRmax呈线性负相关,颈动脉僵硬度变化不明显。
Objective To analyze the changes of carotid artery stiffness in patients with persistent hemodialysis before and after renal transplantation and to explore the relationship between the maximum shear rate (SRmax) and carotid artery stiffness. Methods Totally 31 patients with renal transplant recipients, 31 patients with end-stage renal disease who underwent hemodialysis (end-stage renal disease) and 84 healthy adults of the same sex were selected as the control group. The left and right carotid artery pulse wave velocity (PWV) and the left and right carotid artery SRmax were measured by ultrasound, and the relationship between PWV and SRmax was analyzed. Results (1) The PWV of the left and right carotid arteries of patients with end-stage renal disease and renal transplant recipients were significantly higher than those of the control group (all P <0.05). The left carotid artery SRmax was smaller than that of the control group (all P <0.05). There was no significant difference in PWV between the left and right carotid arteries in the end stage renal disease group and the transplantation kidney group. The SRmax of the right carotid artery of the 3 groups showed no significant difference. (2) In the end stage renal disease group, the PWV of the right carotid artery was greater than that of the left (P <0.05). There was no significant difference in the PWV of the left and right carotid arteries between the control group and the transplantation renal group. There was no significant difference in SRmax between the left and right carotid arteries in the patients with end stage renal disease and renal allograft. In the control group, the SRmax of the left carotid artery was greater than that of the right side (P <0.05). (3) The left and right carotid arteries PWV were positively correlated with age, systolic pressure and diastolic pressure, and negatively correlated with SRmax (all P <0.05). Conclusion There is a linear negative correlation between carotid artery stiffness and SRmax in renal transplant recipients, but no significant change in carotid artery stiffness.