作者见到母女二例硬皮病,并对其家族内的HLA作了观察,查国内尚无报告,现报告如下: 例1 女,56岁。43岁时出现双颊,眼围,双耳肿胀发红并伴有关节痛,不发热。次年双手指,足趾着凉发木变白,继而变紫。四肢远端皮肤肿胀发紧。逐渐变硬,右手中,食指先从指尖呈点状坏死,以后指端发黑坏死,手术截指,相继其它手指发生短缩或坏死,十年 The author saw two cases of scleroderma between mother and daughter, and observed the HLA within her family. No reports were found in China. The report is as follows: Example 1 Female, 56 years old. At the age of 43, cheeks, eyes, ears swollen and accompanied by joint pain, fever. The following year fingers, toes cool hair wood white, and then become purple. Far limbs skin swelling tight. Gradually hardening, the right hand, the index finger from the fingertips were punctate necrosis, after the finger end black necrosis, surgical intercept, followed by shortening or necrosis of other fingers, ten years