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1987年证实一氧化氮(NO)内源性机制的存在与意义以来,NO研究很快得到生物界和医学界的重视。NO机制与消化系统的生理功能和临床病理之间存在着广泛而密切的联系。 用还原性辅酶Ⅰ依赖性黄递酶(NADPHd)组织化学、一氧化氮合成酶(NOS)免疫组织化学方法发现人胃肠道组织中均有NOS分布。NOS在胃肠壁全层均有分布,以环形平滑肌最多。NO参与的功能有:胃肠粘膜血流调节、分泌功能调节、免疫防护屏障、炎症、胃肠动力调节。 先天性巨结肠(HD)病理学上证实为肌层和粘
Since the discovery of the existence and significance of endogenous nitric oxide (NO) in 1987, the NO study has quickly gained the attention of the biologi- cal and medical communities. NO mechanism and the physiological function of the digestive system and clinical pathology there is a wide and close contact. NOS distribution in human gastrointestinal tract was found by NADPHd histochemistry and NOS immunohistochemistry. NOS in the entire wall of the gastrointestinal wall are distributed to ring smooth muscle up. NO involved in the function are: gastrointestinal mucosal blood flow regulation, secretion regulation, immune protection barrier, inflammation, gastrointestinal motility regulation. Hirschsprung’s disease (Histopathology) was confirmed as myometrial and visceral pathology