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目的观察多巴丝肼片口服联合经颅直流电刺激治疗帕金森病非运动症状的效果。方法帕金森病患者100例,随机分成观察组和对照组各50例。两组均口服多巴丝肼片治疗,观察组在此基础上进行高频重复经颅直流电刺激治疗。分别于治疗前和治疗后7 d、1个月采用帕金森氏病评分量表(UPDRS)评价疗效。分别于治疗前和治疗后1个月采用改良Barthel指数评分评价日常生活能力,采用SF-36评分评价生活质量。结果观察组治疗后7 d、1个月UPDRS评分均降低,与治疗前相比,P均<0.05;对照组治疗前后UPDRS评分差异无统计学意义;观察组治疗后7 d、1个月UPDRS评分均降低,与对照组相比,P均<0.05。两组治疗后Barthel指数评分及SF-36评分均较治疗前升高,观察组治疗后1个月Barthel指数评分及SF-36评分高于对照组(P均<0.05)。结论多巴丝肼片口服联合颅直流电刺激治疗帕金森病非运动症状效果较好。
Objective To observe the effect of oral administration of dopa hydrazine tablets combined with transcranial direct current stimulation on non-motor symptoms of Parkinson’s disease. Methods 100 patients with Parkinson’s disease were randomly divided into observation group and control group, 50 cases each. Both groups were treated with oral polysaccharide hydrazine tablets, the observation group on the basis of high-frequency repeated transcranial direct current stimulation treatment. The effect was evaluated by the Parkinson’s Disease Rating Scale (UPDRS) before treatment and at 7 days and 1 month after treatment, respectively. The modified Barthel index was used to assess the daily living ability before treatment and one month after treatment, and the quality of life was evaluated by SF-36. Results The UPDRS scores of the observation group decreased on the 7th and the 1th month after treatment, P <0.05 compared with those before treatment. The UPDRS scores of the control group had no significant difference before and after treatment. The UPDRS The scores were lower, P <0.05 compared with the control group. The Barthel index and SF-36 scores of both groups were higher than those before treatment. The Barthel index and SF-36 score of the observation group were higher than those of the control group one month after treatment (P <0.05). Conclusions The combination of oral administration of dopachizine tablets and cranial DC stimulation for non-motor symptoms of Parkinson’s disease is effective.