目的 探讨血清免疫球蛋白G_4(IgG_4)与免疫性肝损伤疾病的相关性，为方便快捷做出诊断提供准确指标?方法 选取2018年1月至2018年9月在本院接受治疗的不同程度肝损伤患者共计158例，根据确诊肝损伤以及疾病的不同，为患者分为3组，其中，慢性乙型肝炎组54例，原发性胆汁肝硬化组53例，自身免疫性肝炎组51例，对3组患者的血清各项生化指标进行回顾性分析，比较血清中血清免疫球蛋白G_4(IgG_4)水平自身抗体差异等指标?结果 慢性乙型肝炎组的静脉总胆红素(TBiL)?天冬氨酸转氨酶(AST)水平较其余“,”Objective To explore the correlation between serum immunoglobulin G4(IgG4)and immune liver injury diseases， and to provide accurate indexes for convenient and rapid diagnosis. Methods A total of 158 patients with different degrees of liver injury treated in our hospital from January 2018 to September 2018 were selected. According to the confirmed liver injury and diseases， the patients were divided into three groups， Including 54 cases of chronic hepatitis B， 53 cases of primary biliary cirrhosis and 51 cases of autoimmune hepatitis. The serum biochemical indexes of the three groups were analyzed retrospectively， the levels of serum immunoglobulin G4(IgG4) and autoantibodies were compared. Results The levels of total bilirubin (TBiL)and ALT(ALT) in the chronic hepatitis B group were significantly higher than those in the other two groups， but there was no statistical difference (P>0.05). The levels of glutamic pyruvic transaminase (ALT) in the group were significantly higher than those in the other two groups (P0.05)， the immunoglobulin M(IgM) level increased significantly compared with the chronic hepatitis B group (P<0.05); and the immunoglobulin G(IgG) index in the immunological liver inflammation group was higher than that in the chronic hepatitis B group， with statistical difference (P<0.05). IgG4 in immune hepatitis group increased more significantly than that in chronic hepatitis B group and cirrhosis group (P<0.05). The positive rates of anti nuclear antibody (ANA)， anti ribonucleoprotein (nRNP)， anti Ro-52 antibody and anti Sjogren syndrome antigen B(SSB) in group A were higher than those in group B (P<0.05). Conclusion There is a certain relationship between serum immunoglobulin G4(IgG4) and immune liver injury diseases. By detecting the level of serum immunoglobulin G4(IgG4)， immune liver injury related diseases can be further diagnosed.The detection is convenient，fast and accurate，which is worthy of popularization.