血管是感受血液流动最敏感的器官,研究证实血液流动对血管产生的作用力是血管壁细胞生长的一种重要胞外信号,对血管结构与功能变化起着关键的调节作用[1]。最近国内外报道血管应力一旦发生改变,血管内皮细胞则可通过跨膜蛋白、信号转导和基因表达等将力学信息传递到细胞内,再经 Blood vessels are the most sensitive organs that feel blood flow. Studies have shown that the force exerted by blood flow on blood vessels is an important extracellular signal for the growth of vascular wall cells, and plays a key regulatory role on the changes of vascular structure and function [1]. Recent reports of vascular stress at home and abroad once changed, vascular endothelial cells can transmembrane proteins, signal transduction and gene expression will be mechanical information to the cell, and then by