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目的探讨兰索拉唑联合克拉霉素治疗幽门螺杆菌感染性胃病的临床效果。方法选取幽门螺杆菌感染性胃病患者68例,随机分为观察组和对照组各34例。对照组使用常规治疗方法,观察组使用兰索拉唑联合克拉霉素治疗,比较2组治疗效果、幽门螺杆菌根除率及不良反应发生率。结果观察组总有效率为94.12%,高于对照组的70.59%,差异有统计学意义(P<0.05);观察组幽门螺杆菌根除率为91.18%,高于对照组的73.53%,差异有统计学意义(P<0.05);观察组不良反应发生率为5.88%,低于对照组的26.47%,差异有统计学意义(P<0.05)。结论兰索拉唑联合克拉霉素治疗幽门螺杆菌感染性胃病临床效果良好,可快速有效地清除幽门螺杆菌,且安全性高,值得临床推广。
Objective To investigate the clinical efficacy of lansoprazole combined with clarithromycin in the treatment of Helicobacter pylori infection in stomach. Methods 68 patients with Helicobacter pylori infection gastritis were randomly divided into observation group and control group, 34 cases each. The control group was treated with conventional therapy. The observation group was treated with lansoprazole combined with clarithromycin. The treatment effect, the eradication rate of Helicobacter pylori and the incidence of adverse reactions in the two groups were compared. Results The total effective rate of observation group was 94.12%, which was higher than that of control group (70.59%), the difference was statistically significant (P <0.05). The eradication rate of Helicobacter pylori in observation group was 91.18%, which was higher than that of control group Statistical significance (P <0.05). The incidence of adverse reactions in the observation group was 5.88%, which was lower than that in the control group (26.47%), the difference was statistically significant (P <0.05). Conclusion The combination of lansoprazole and clarithromycin in the treatment of Helicobacter pylori infection in the stomach with good clinical results, can quickly and effectively remove Helicobacter pylori, and high safety, worthy of clinical promotion.