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目的观察补阳还五汤联合阿司匹林对缺血性脑中风患者的临床疗效。方法将缺血性脑中风患者86例,随机分为两组。对照组应用阿司匹林等常规治疗,治疗组在对照组治疗基础上加用补阳还五汤。12周后观察疗效并根据神经功能缺损评分标准(NIHSS)评估两组患者神经功能缺损评分,并检测患者治疗前后全血黏度、红细胞电泳时间、红细胞压积(HCT)、纤维蛋白原(Fib)等指标。结果治疗组总有效率明显高于对照组(P<0.05);两组治疗后NIHSS均低于治疗前,治疗组低于对照组(P<0.05);治疗组MODS发生率和病死率低于对照组(P<0.05);两组治疗后全血粘度(高切、低切)、红细胞电泳时间、HCT和Fib均低于治疗前(P<0.05),治疗组均低于对照组(P<0.05)。结论补阳还五汤联合阿司匹林治疗缺血性脑中风患者能够显著减轻神经功能缺损,改善其血液流变学指标,值得临床推广应用。
Objective To observe the clinical effects of Buyang Huanwu Decoction combined with aspirin on ischemic stroke patients. Methods 86 patients with ischemic stroke were randomly divided into two groups. The control group, aspirin and other conventional treatment, the treatment group in the control group based on the treatment with Buyanghuanwu. After 12 weeks, the curative effect was observed and the neurological deficit score was evaluated according to the NIHSS. The whole blood viscosity, erythrocyte electrophoresis time, hematocrit (HCT), fibrinogen (Fib) And other indicators. Results The total effective rate in the treatment group was significantly higher than that in the control group (P <0.05). The NIHSS in both groups were significantly lower than those in the control group before and after treatment (P <0.05). The morbidity and mortality of MODS in the treatment group were lower than those in the control group (P <0.05). The whole blood viscosity (high-cut, low-cut), erythrocyte electrophoresis time, HCT and Fib in both groups after treatment were lower than those before treatment <0.05). Conclusion The treatment of Buyang Huanwu Decoction combined with aspirin in patients with ischemic stroke can significantly reduce neurological deficits and improve the hemorheological parameters, which is worthy of clinical application.