红斑狼疮合并大面积皮肤坏死较少见 ,我科 1999年收治 1例 ,在全身综合性治疗的基础上 ,选择有效的抗生素并行抗红斑狼疮药物治疗行扩创植皮术 ,疗效较满意 ,现报道如下。1　临床资料患者男 ,30岁 ,于 1999年 6月 8日以红斑狼疮合并双小腿、双足广泛皮肤及部分浅层肌肉坏死入院 Lupus erythematosus with large area of ​​skin necrosis is rare, our department in 1999 admitted to a case of comprehensive treatment in the body, based on the selection of effective antibiotics parallel anti-lutein drug treatment line augmentation skin grafting, the effect is more satisfactory, are reported as follows. 1 Clinical data Patient male, 30 years old, on June 8, 1999 lupus erythematosus merged with double lower leg, extensive skin of both feet and partial shallow muscular necrosis admitted