患者,女,24岁。1月前受凉后出现发热、咽痛,体温高达40℃。抗炎后发热消退,但又出现咳嗽、咳痰。10 d前注射克林霉素1 d后出现无尿,伴呕吐、颜面及双下肢水肿,入当地医院查Scr 897μmol／L,BUN 9．4 mmol／L。予抗感染、护肾、利尿及支持治疗,行3次血液透析,仍无尿, 后转入我科。既往有青霉素过敏史。入院体检贫血貌,面部 Patient, female, 24 years old. 1 month ago after a cold fever, sore throat, body temperature up to 40 ℃. Anti-inflammatory fever subsided, but there cough, sputum. An anuria, vomiting, facial and lower extremity edema occurred after 10 days of clindamycin injection. Scr 897 μmol / L and BUN 9.4 mmol / L were taken into the local hospital. To anti-infection, kidney protection, diuretic and supportive care, hemodialysis three times, still no urine, transferred to our department. Past history of penicillin allergy. Admission examination anemia appearance, face