论文部分内容阅读
目的:针对平胃散燥湿健脾、行气和胃的功效,复制相应的病理模型,将方中药物炮制前后分别组成平胃散进行药效学比较研究,探讨方中药物炮制入药的合理性。方法:将70只小鼠随机等分为正常组、模型组、阳性药物组、生品组、麸炒苍术组、炙甘草组、炮制品组,除正常组外,其余各组小鼠采用饮食不节、外湿过盛、情志不遂的综合方法复制湿困脾胃证病理模型,给药量约为0.01 m L·g~(-1);以小肠推进率、胃残留率及力竭游泳时间等为平胃散干预治疗的评价指标。结果:与正常组相比,模型组胃排空、小肠推进及抗疲劳能力极显著下降,说明造模成功。与模型组相比,各给药组均有明显的改善作用,其中阳性组与炮制品平胃散组的改善作用最显著。结论:平胃散在改善湿困脾胃证时,苍术与甘草以炮制品入药的药效更佳。
OBJECTIVE: To study the efficacy of Pingwei Powder in the treatment of damp and spleen, qi and stomach, and to copy the corresponding pathological models. Methods: Seventy mice were randomly divided into normal group, model group, positive drug group, raw product group, bran fried herb group, Zhigancao group and processed product group. Except normal group, the other groups were fed with diet The section of pathological model of damp-stubborn spleen-stomach syndrome was duplicated by a comprehensive method of non-section, over-wet and over-ambitious. The dose was about 0.01 m L · g -1. The small intestine propulsion rate, gastric residual rate and exhaustive swimming Time, etc. Ping Ping San intervention in the evaluation of indicators. Results: Compared with the normal group, the gastric emptying, small intestine propulsion and anti-fatigue ability of the model group decreased significantly, indicating that the model was successful. Compared with the model group, each treatment group had a significant improvement, of which the positive group and processed product Pingwei powder group to improve the most significant effect. Conclusion: Pingwei Powder is effective in improving damp-qi and spleen-stomach syndrome when herbal medicine and licorice root are processed into products.