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目的观察健胃愈疡颗粒对胃溃疡大鼠胃黏膜氨基己糖及磷脂含量的影响,从而探讨其抗溃疡复发作用的机制。方法拟Okabe改良法制作SD大鼠胃溃疡模型,腹腔注射白介素-1β(IL-1β)制作胃溃疡复发模型;测定大鼠胃黏膜组织中磷脂和氨基己糖的含量。结果在灌胃第10日和第90日,健胃愈疡组磷脂和氨基己糖的含量显著高于模型组和正常对照组。结论健胃愈疡颗粒剂抗复发的作用机理可能与影响胃黏膜的疏水性有关。
Objective To observe the effect of Jianwei Yuyang granules on the content of hexosamine and phospholipid in gastric mucosa of gastric ulcer rats, and to explore the mechanism of its anti-ulcer recurrence. Methods Gastric ulcer model of SD rats was prepared by modified Okabe method. The recurrence model of gastric ulcer was made by intraperitoneal injection of interleukin-1β (IL-1β). The contents of phospholipids and hexosamines in rat gastric mucosa were determined. Results On the 10th and 90th day after intragastric administration, the contents of phospholipids and hexosamines in the Jianwei Yuyang group were significantly higher than those in the model group and the normal control group. Conclusion The anti-relapse mechanism of Jianweiyuyang granule may be related to the hydrophobicity of gastric mucosa.